Granulation is a process of size enlargement whereby small particles are gathered into larger, permanent aggregates in which the original particles can still be identified.

The term “granulation” regularly refers to processes whereby aggregates with sizes ranging from about 0.1 to 2.0 mm are produced. The term “palletisation” is used synonymously with granulation, but in pharmacy this term is usually refers to the manufacture of aggregates, preferably spherical, with a narrow size distribution in the range of about 0.5 to 1.5 mm.